Ficha asig 2 Postgrado en Microbiota

PRINCIPIOS DE LA MICROBIOTA Y SU IMPLICACIÓN EN LA ENFERMEDAD

Postgrado en Microbiota

Asignatura 2

Principios de la microbiota y su implicación en la enfermedad

Datos generales

- - - Profesor: Rubén López Aladid.
    - Idioma de las clases expositivas: Castellano.

Temas de la Asignatura

1- Microbiota y sistema inmune
2- Microbiota y sistema inmune relacionado con la enfermedad
3- Microbiota respiratorio
4- Microbiota y marcadores inflamatorios en las enfermedades respiratorias crónicas: Las bronquiectasias
5- Microbiota, obesidad y huésped / Medicina personalizada mediante análisis de microbioma Evaluación y calificación
Examen tipo test – 100% de la nota final de la asignatura.
*Es imprescindible una nota mínima de 50%.

Bibliografía

WHO. Obesity and overweight. [Internet]. 2021. Available from:
https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight.
Ng M, Fleming T, Robinson M, Thomson B, Graetz N, Margono C, et al. Global,
regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2014 Aug 30;384(9945):766-81.
Visser M, Bouter LM, McQuillan GM, Wener MH, Harris TB. Low-grade systemic inflammation in overweight children. Pediatrics. 2001;107(1):E13.
Mraz M, Haluzik M. The role of adipose tissue immune cells in obesity and low-grade inflammation. Vol. 222, Journal of Endocrinology. BioScientifica Ltd.; 2014. p. 113-27.
Razquin C, Marti A, Martinez JA. Evidences on three relevant obesogenes: MC4R, FTO and PPARγ. Approaches for personalized nutrition. Mol Nutr Food Res. 2011;55(1):136-49.
Vaisse C, Clement K, Guy-Grand B, Froguel P. A frameshift mutation in human MC4R is associated with a dominant form of obesity. Nat Genet. 1998;20(2):113-4.
Yeo GSH, Farooqi IS, Aminian S, Halsall DJ, Stanhope RG, O’Rahilly S. A frameshiftmutation in MC4R associated with dominantly inherited human obesity. Nat Genet. 1998;20(2):111-2.Diabetes. 1998;47(4):507-14.
Spiegelman BM. PPAR-gamma: adipogenic regulator and thiazolidinedione receptor.
Vimaleswaran KS, Loos RJF. Progress in the genetics of common obesity and type 2 diabetes. Expert Rev Mol Med. 2010 Feb;12.
Scuteri A, Sanna S, Chen WM, Uda M, Albai G, Strait J, et al. Genome-Wide Association Scan Shows Genetic Variants in the FTO Gene Are Associated with Obesity-Related Traits. PLoS Genet. 2007 Jul;3(7):1200-10.
Oriach CS, Robertson RC, Stanton C, Cryan JF, Dinan TG. Food for thought: The roleof nutrition in the microbiota-gut-brain axis. Clin Nutr Exp. 2016 Apr 1;6:25-38.
Kumar H, Lund R, Laiho A, Lundelin K, Ley RE, Isolauri E, et al. Gut Microbiota as anEpigenetic Regulator: Pilot Study Based on Whole-Genome Methylation Analysis. 2014;
Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, Gordon JI. An obesity-associated gut microbiome with increased capacity for energy harvest. Nat 2006 4447122. 2006 Dec 21;444(7122):1027-31.
Tilg H, Kaser A. Gut microbiome, obesity, and metabolic dysfunction. J Clin Invest. 2011 Jun 1;121(6):2126-32.
Devaux CA, Raoult D. The microbiological memory, an epigenetic regulator governing the balance between good health and metabolic disorders. Front Microbiol. 2018 Jun26;9(JUN):1379.
Cuevas-Sierra A, Ramos-Lopez O, Riezu-Boj JI, Milagro FI, Martinez JA. Diet, Gut Microbiota, and Obesity: Links with Host Genetics and Epigenetics and Potential Applications. Adv Nutr. 2019 Jan 1;10(suppl_1):S17-30.
Allin KH, Nielsen T, Pedersen O. MECHANISMS IN ENDOCRINOLOGY: Gut microbiota in patients with type 2 diabetes mellitus. Eur J Endocrinol. 2015 Apr 1;172(4):R167-77.
Ley RE, Turnbaugh PJ, Klein S, Gordon JI. Human gut microbes associated with obesity. Nat 2006 4447122. 2006 Dec 21;444(7122):1022-3.
Pascal V, Pozuelo M, Borruel N, Casellas F, Campos D, Santiago A, et al. A microbial signature for Crohn’s disease. Gut. 2017 May 1;66(5):813-22.
Maeda Y, Takeda K. Role of Gut Microbiota in Rheumatoid Arthritis. J Clin Med 2017, Vol 6, Page 60. 2017 Jun 9;6(6):60.
Janssen AWF, Houben T, Katiraei S, Dijk W, Boutens L, Van Der Bolt N, et al. Modulation of the gut microbiota impacts nonalcoholic fatty liver disease: a potential role for bile acids. J Lipid Res. 2017 Jul 1;58(7):1399-416.
Yu TC, Guo F, Yu Y, Sun T, Ma D, Han J, et al. Fusobacterium nucleatum Promotes Chemoresistance to Colorectal Cancer by Modulating Autophagy. Cell. 2017 Jul 27;170(3):548-563.e16.
Yuille S, Reichardt N, Panda S, Dunbar H, Mulder IE. Human gut bacteria as potent class I histone deacetylase inhibitors in vitro through production of butyric acid and valeric acid. PLoS One. 2018 Jul 1;13(7):e0201073.